发明名称 |
COMBINATIONS OF MENINGOCOCCAL FACTOR H BINDING PROTEINS |
摘要 |
The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence. |
申请公布号 |
EP2585106(A1) |
申请公布日期 |
2013.05.01 |
申请号 |
EP20110738818 |
申请日期 |
2011.06.24 |
申请人 |
NOVARTIS AG |
发明人 |
ARICO, BEATRICE MARIA;BRUNELLI, BRUNELLA;COMANDUCCI, MAURIZIO;PIZZA, MARIAGRAZIA;SAVINO, SILVANA;SCARSELLI, MARIA |
分类号 |
A61K39/095;A61P31/04 |
主分类号 |
A61K39/095 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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