发明名称 |
Process for the preparation of (S)-N-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxyamide |
摘要 |
A description is given here of a novel process for the synthesis of N-carboxyanhydride of formula VIby reacting (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid with triphosgene in dioxane; a description is also given of a process for the synthesis of (S)-N-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxyamide by treating the N-carboxyanhydride VI so obtained with tert-butylamine.
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申请公布号 |
US6340760(B1) |
申请公布日期 |
2002.01.22 |
申请号 |
US20000478690 |
申请日期 |
2000.01.06 |
申请人 |
CLARIANT LSM ITALIA S.P.A |
发明人 |
BELLANI PIETRO;FRIGERIO MARCO |
分类号 |
C07D217/26;C07D498/04;(IPC1-7):C07D491/048;C07D491/04 |
主分类号 |
C07D217/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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