发明名称 |
RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY |
摘要 |
<p>Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics and research.</p> |
申请公布号 |
EP1945762(B1) |
申请公布日期 |
2013.05.01 |
申请号 |
EP20060826293 |
申请日期 |
2006.10.18 |
申请人 |
PRECISION BIOSCIENCES |
发明人 |
HELLINGA, HOMME, W.;SMITH, JAMES, JEFFERSON;JANTZ, DEREK |
分类号 |
C12N9/22 |
主分类号 |
C12N9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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