8-substituted benzoazepines as toll-like receptor modulators, pharmaceutical compositions comprising them and their use in the manufacture of medicaments

摘要

Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8 The compositions and methods have use in the treatment of autoimmunity, inflammation allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.