发明名称 |
Monomethylvaline compounds , uses thereof and conjugates, pharmaceutical compositions, assays and articles comprising the same |
摘要 |
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo. |
申请公布号 |
IL175247(A) |
申请公布日期 |
2013.04.30 |
申请号 |
IL20060175247 |
申请日期 |
2006.04.27 |
申请人 |
SEATTLE GENETICS INC. |
发明人 |
|
分类号 |
A61K;A61K38/00;A61K38/06;A61K39/395;A61K47/48;C07D;C07K;C07K16/46 |
主分类号 |
A61K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|