发明名称 |
Methods for alleviating deleterious effects of 3-deoxyglucosone |
摘要 |
Disclosed is a class of compounds which inhibit the enzymatic conversion of fructose-lysine into fructose-lysine-3-phosphate in an ATP dependent reaction in a newly discovered metabolic pathway. According to the normal functioning on this pathway, fructose-lysine-3-phosphate (FL3P) is broken down to form free lysine, inorganic phosphate and 3-deoxyglucosone (3DG), the latter being a reactive protein modifying agent. 3DG can be detoxified by reduction to 3-deoxyfructose (3DF), or it can react with endogenous proteins to form advanced glycation end-product modified proteins (AGE-proteins) Also disclosed are therapeutic methods of using such inhibitors to alleviate deleterious effects of 3DG. |
申请公布号 |
US8431527(B2) |
申请公布日期 |
2013.04.30 |
申请号 |
US20100911195 |
申请日期 |
2010.10.25 |
申请人 |
BROWN TRUMAN R.;KAPPLER FRANCIS;FOX CHASE CANCER CENTER |
发明人 |
BROWN TRUMAN R.;KAPPLER FRANCIS |
分类号 |
A61K38/00;A61K31/00;A61K31/13;A61K31/197;A61K31/198;A61K31/275;A61K31/5375;C07H19/20;G01N33/66 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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