发明名称 |
METHODS FOR DETERMINING CANCER RESISTANCE TO HISTONE DEACETYLASE INHIBITORS |
摘要 |
Described herein are methods and compositions for determining whether a particular cancer is resistant to or susceptible to a histone deacetylase inhibitor or to histone deacetylase inhibitors. The methods include analysis of the expression levels of at least four biomarker genes associated with response to a histone deacetylase inhibitor. Also described herein are methods and compositions for increasing the likelihood of a therapeutically effective treatment in a patient, comprising an analysis of the expression levels of at least four biomarker genes associated with response to a histone deacetylase inhibitor. Also described herein are isolated populations of nucleic acids derived from a cancer sensitive to or resistant to a histone deacetylase inhibitor. Further described are kits and indications that are used in conjunction with the aforementioned methods and compositions. |
申请公布号 |
EA017985(B1) |
申请公布日期 |
2013.04.30 |
申请号 |
EA20090000927 |
申请日期 |
2008.01.30 |
申请人 |
PHARMACYCLICS, INC. |
发明人 |
BUGGY JOSEPH, J.;BALASUBRAMANIAN SRIRAM |
分类号 |
C12Q1/68;C40B40/06 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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