METHOD FOR SUPPRESSING TUMOR GROWTH BY BLOCKING FIBROBLAST GROWTH FACTOR RECEPTOR, AND METHOD FOR DIAGNOSING MALIGNANT NEOPLASMS

摘要

The invention pertains to the field of medicine and relates to a method for suppressing the growth of tumors, which comprises blocking the pathway of "human fibroblast growth factor / human fibroblast growth factor receptor 1 (domains II and IIIc)", and to a method for diagnosing malignant neoplasms. This pathological pathway leads to an excessive proliferation of tumor cells and to the formation of new vessels accompanied by the growth of primary tumors and metastases. This pathway also represents an independent mechanism of tumor resistance to pharmaceutical preparations affecting other pathological pathways. Blocking the pathway of "fibroblast growth factor / fibroblast growth factor receptor 1" using various substances that neutralize the receptor by binding only to domains II and IIIc thereof results in the inhibition or slow-down of tumor growth. This receptor can also be used as a target for targeted delivery of diagnostic agents as it is present in large amounts in the cells of numerous tumors. The invention is advantageous in that it makes it possible to develop new agents for diagnosing and treating diseases related to excessive proliferation and neovascularization.