发明名称 |
AMYLIN AGONIST COMPOUNDS FOR ESTROGEN-DEFICIENT MAMMALS |
摘要 |
<p>Provided herein are methods to treat estrogen deficiency in mammals by administering amylin agonist compounds. Also provided herein are methods to treat obesity and overweight in estrogen-deficient mammals; methods to reduce or maintain body weight and/or body fat in estrogen-deficient mammals; and methods to increase Bdnf levels in mammals by administering effective amounts of amylin agonist compounds. The estrogen deficiency may be caused by menopause, perimenopause, post-menopause, ovarian dysfunction, an overectomy, a hysterectomy, and the like. The amylin agonist compounds may be any known in the art or described herein, such as pramlintide, davalintide, or SEQ ID NO: 142.</p> |
申请公布号 |
EP2416797(A4) |
申请公布日期 |
2013.04.24 |
申请号 |
EP20100762535 |
申请日期 |
2010.04.09 |
申请人 |
AMYLIN PHARMACEUTICALS, LLC;ASTRAZENECA PHARMACEUTICALS LP |
发明人 |
ROTH, JONATHAN, D.;TREVASKIS, JAMES, L.;PARKES, DAVID, G. |
分类号 |
A61K38/22;A61K38/23;A61P3/04;C07K14/575 |
主分类号 |
A61K38/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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