ANTICANCER COMPOSITION CONTAINING THE BENZOHYDROXYMETHOXYCHALCONE

摘要

PURPOSE: A benzohydroxymethoxychalcone compound is provided to have an excellent growth-inhibiting effect against cancer cells, and killing functions by caspase activity. CONSTITUTION: A benzohydroxymethoxychalcone compound is represented by chemical formula 1. A manufacturing method of the benzohydroxymethoxychalcone comprises: a step of dissolving 2-hydroxy-4-methoxy-1-acetophenone and 1-naphthaaldehyde into ethanol; a step of adding a KOH solution to the mixture solution; a step of cooling the mixture solution at 4 deg. C; a step of neutralizing the mixed solution, and extracting the neutralized solution twice by chloroform; a step of adding magnesium sulphate into the extracted organic solvent, and removing water; and a step of vacuum filtrating and purifying the mixture by a pipe chromatography.