发明名称 |
Microwave-assisted peptide synthesis |
摘要 |
An instrument and method for accelerating the solid phase synthesis of peptides are disclosed. The method includes the steps of deprotecting a protected first amino acid linked to a solid phase resin by admixing the protected linked acid with a deprotecting solution in a microwave transparent vessel while irradiating the admixed acid and solution with microwaves, activating a second amino acid, coupling the second amino acid to the first acid while irradiating the composition in the same vessel with microwaves, and cleaving the linked peptide from the solid phase resin by admixing the linked peptide with a cleaving composition in the same vessel while irradiating the composition with microwaves.
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申请公布号 |
US8426560(B2) |
申请公布日期 |
2013.04.23 |
申请号 |
US201113294478 |
申请日期 |
2011.11.11 |
申请人 |
COLLINS JONATHAN MCKINNON;LAMBERT JOSEPH JOSHUA;COLLINS MICHAEL JOHN;CEM CORPORATION |
发明人 |
COLLINS JONATHAN MCKINNON;LAMBERT JOSEPH JOSHUA;COLLINS MICHAEL JOHN |
分类号 |
A61K38/00;B01J19/12;C07K1/04;C07K1/08;C07K5/00;C07K5/093;C07K7/00;C07K7/06;C07K16/00;C07K17/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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