NEW PROTEINS H5, MOLECULES OF NUCLEIC ACIDS THAT CODE THEM AND VECTORS, AND THEIR APPLICATION IN MEDICINE

摘要

FIELD: biotechnologies.SUBSTANCE: protein of flu virus hemagglutinin is disclosed, as well as a molecule of nucleic acid, which codes such protein, a vaccine for treatment or prevention of infections, which are mediated by a flu virus, a set and also methods to produce protein and vaccines. The protein of hemagglutinin H5 of the flu virus is characterised by the fact that in the position 223 of the series it is substituted with asparagine, and the second lysine is built into the position 328.EFFECT: modified protein has improved immunogenic properties.14 cl, 1 tbl, 4 ex