发明名称 |
METHOD OF TREATING AUTOIMMUNE DISEASES WITH INTERFERON-BETA AND IL-2R ANTAGONIST |
摘要 |
Disclosed is a method of administering an interleukin-2 receptor (IL-2R) antagonist to a subject to treat an autoimmune disease. In particular embodiments, the IL-2R antagonist is an anti-IL-2R monoclonal antibody specific for one or more chains of the IL-2R, such as the alpha-chain, for example daclizumab. In other particular embodiments the autoimmune disease is multiple sclerosis. In certain embodiments administration of interferon-beta is combined with administration of an antagonist of the IL-2R to provide significant clinical improvement in a subject with an autoimmune disease. |
申请公布号 |
US2013095069(A1) |
申请公布日期 |
2013.04.18 |
申请号 |
US201213612763 |
申请日期 |
2012.09.12 |
申请人 |
MARTIN ROLAND;MCFARLAND HENRY;BIELEKOVA BIBIANA;WALDMANN THOMAS;THE GOVERNMENT OF THE USA AS REPRESENTED BY THE SECRETARY OF THE DEPT OF HEALTH AND HUMAN SERVICES |
发明人 |
MARTIN ROLAND;MCFARLAND HENRY;BIELEKOVA BIBIANA;WALDMANN THOMAS |
分类号 |
A61K39/395;A61K45/00;A61K31/7052;A61K35/30;A61K38/00;A61K38/21;A61K39/00;A61P25/00;A61P37/02;C07K16/28 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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