发明名称 |
THE USE OF (2R, 6R)-HYDROXYNORKETAMINE, (S)-DEHYDRONORKETAMINE AND OTHER STEREOISOMERIC DEHYDRO AND HYDROXYLATED METABOLITES OF (R,S)- KETAMINE IN THE TREATMENT OF DEPRESSION AND NEUROPATHIC PAIN |
摘要 |
The disclosure provides pharmaceutical preparations containing (2R,6R)-hydroxynorketamine, or (R)- or (S)-dehydronorketamine, or other stereoisomeric dehydro or hydroxylated ketamine metabolite. (2R,6R)-hydroxynorketamine The disclosure also provides novel ketamine metabolite prodrugs. The disclosure provides methods of treating, bipolar depression, major depressive disorder, neuropathic and chronic pain, including complex regional pain disorder (CRPS) by administering a purified ketamine metabolite or a ketamine metabolite prodrug directly to patients in need of such treatment. |
申请公布号 |
WO2013056229(A1) |
申请公布日期 |
2013.04.18 |
申请号 |
WO2012US60256 |
申请日期 |
2012.10.15 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;THE COOPER HEALTH SYSTEM;WAINER, IRVING W.;MOADDEL, RUIN;BERNIER, MICHEL;ZARATE, CARLOS A.;TORJMAN, MARC C.;GOLDBERG, MICHAEL E. |
发明人 |
WAINER, IRVING W.;MOADDEL, RUIN;BERNIER, MICHEL;ZARATE, CARLOS A.;TORJMAN, MARC C.;GOLDBERG, MICHAEL E. |
分类号 |
C07C225/20;A61K31/122;A61K31/133;A61P25/00;A61P25/04;A61P25/28;C07C237/02;C07D295/145;C07D295/155 |
主分类号 |
C07C225/20 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|