PRODUCTION OF FERTILE XY FEMALE ANIMALS FROM XY ES CELLS
摘要
Methods and compositions are described for making phenotypically female fertile animals from XY donor cells and suitable host embryos. Culture media and methods are provided for maintaining XY donor cells in culture that after introduction into a host embryo and gestation in a suitable host will result in fertile XY female animals. Methods and compositions are described for making fertile female animals in an F0 generation from a donor XY cell and a host embryo, as are methods for making F1 progeny that are homozygous for a modification from a heterozygous F0 fertile male and a heterozygous F0 fertile female sibling.
申请公布号
EP2579711(A1)
申请公布日期
2013.04.17
申请号
EP20110729215
申请日期
2011.06.10
申请人
REGENERON PHARMACEUTICALS, INC.
发明人
AUERBACH, WIJTEK;DECHIARA, THOMAS;POUEYMIROU, WILLIAM;FRENDEWAY, DAVID;VALENZUELA, DAVID