发明名称 |
PARVOVIRUS FOR TREATMENT OF TUMOURS BY INTRANASAL APPLICATION |
摘要 |
Described is the use of an oncolytic parvovirus for the manufacture of a medicament for the treatment of a tumor and/or tumor metastases, in particular a brain tumor, by intranasal administration. A preferred parvovirus is H1-PV. Intranasal parvotherapy can improve the prognosis of said tumors. Parvovirus H1 infection leads to killing of tumor cells but does not harm normal brain cells. Thus, the intranasal use of a parvovirus like H1, a related virus or vectors based on such viruses offers the chance of tumor specific therapy without severe neurological side effects. |
申请公布号 |
EP2579885(A1) |
申请公布日期 |
2013.04.17 |
申请号 |
EP20110730197 |
申请日期 |
2011.06.09 |
申请人 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM |
发明人 |
ROMMELAERE, JEAN;KIPRIJANOVA, IRINA;SCHLEHOFER, JÖRG;AYACHE, ALI;FISCHER, MANUEL |
分类号 |
A61K35/76;A61K48/00;A61P35/00 |
主分类号 |
A61K35/76 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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