摘要 |
Described are novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are useful in the treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; atherosclerosis; cancer; cachexia; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; ARDS; psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; asthma; COPD; bone resorption diseases; multiple sclerosis; sepsis; septic shock; toxic shock syndrome and fever. More particularly these compounds are useful as PDE4 inhibitors and are useful for treating PDE4 mediated diseases.
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申请人 |
SRINIVAS VISWESWARA AKELLA SATYA SURYA;TADIPARTHI RAVIKUMAR;SHARMA GANAPAVARAPU VEERA RAGHAVA;SAPPANIMUTHU THIRUNAVUKKARASU;BHAKIARAJ DURAIRAJ PETER;KACHHADIA VIRENDRA;NARASIMHAN KILAMBI;THARA SATHYA NARAYANA;RAJAGOPAL SRIRAM;NARAYANAN SUKUNATH;PARAMESWARAN VENKATESAN;JANARTHANAM VENKATESAN;NARAYANAM MARUTHIKUMAR;GADDE SATHYANARAYANA;RAMACHANDRAN UMA;BALASUBRAMANIAN GOPALAN;SURENDRAN NARAYANAN;NARAYANAN SHRIDHAR;VISHWAKARMA LOLAKNATH SANTOSH;SAXENA SANJEEV;GADDAM NISHIKANTH REDDY;ORCHID CHEMICALS & PHARMACEUTICALS LIMITED |
发明人 |
SRINIVAS VISWESWARA AKELLA SATYA SURYA;TADIPARTHI RAVIKUMAR;SHARMA GANAPAVARAPU VEERA RAGHAVA;SAPPANIMUTHU THIRUNAVUKKARASU;BHAKIARAJ DURAIRAJ PETER;KACHHADIA VIRENDRA;NARASIMHAN KILAMBI;THARA SATHYA NARAYANA;RAJAGOPAL SRIRAM;GADDAM OM REDDY;NARAYANAN SUKUNATH;PARAMESWARAN VENKATESAN;JANARTHANAM VENKATESAN;NARAYANAM MARUTHIKUMAR;GADDE SATHYANARAYANA;RAMACHANDRAN UMA;BALASUBRAMANIAN GOPALAN;SURENDRAN NARAYANAN;NARAYANAN SHRIDHAR;VISHWAKARMA LOLAKNATH SANTOSH;SAXENA SANJEEV |