METHOD FOR PRODUCING OLIGODENDROCYTE PRECURSOR CELL FROM PLURIPOTENT STEM CELL

摘要

The present invention relates to a method for producing an oligodendrocyte precursor cell from a pluripotent stem cell and a neural precursor cell produced by the method, and more specifically, to a method comprising the steps of: (a) obtaining a cell population including the neural precursor cell by differentiating the pluripotent stem cell into a neural rosette; (b) putting an A2B5-specifically binding antibody into contact with the cell population; (c) separating an A2B5 positive cell to which the antibody to A2B5 is bound; and (d) differentiating the A2B5 positive cell into the oligodendrocyte precursor cell. According to the present invention, a more efficient and stable method for producing the oligodentrocyte precursor cell compared to existing methods can be established, and indicators which are appropriate for tracing a differentiation process can be provided. Also, the disadvantage of not maintaining a constant differentiation rate due to a variable during a differentiation process can be overcome, and a more pure production method can be provided by shortening the differentiation process.