IDENTIFYING MARKERS OF CALORIC RESTRICTION AND CALORIC RESTRICTION MIMETICS
摘要
Markers of caloric restriction (CR) can be identified in a selected tissue by exposing an animal to CR conditions and selecting one or more genes differentially expressed in response to CR conditions in multiple subject groups. A candidate compound can be screened for likely ability to mimic the effects of CR when administered to an animal by comparing the tissue levels of expression products of the genes in animals treated with the candidate compound to those of animals subjected to CR.
申请公布号
WO2012174484(A3)
申请公布日期
2013.04.11
申请号
WO2012US42822
申请日期
2012.06.15
申请人
NSE PRODUCTS, INC.;MASTALOUDIS, ANGELA;WOOD, STEVE;PROLLA, TOMAS ALBERTO;BARGER, JAMIE LOUIS;WEINDRUCH, RICHARD;CHANG, JOSEPH
发明人
MASTALOUDIS, ANGELA;WOOD, STEVE;PROLLA, TOMAS ALBERTO;BARGER, JAMIE LOUIS;WEINDRUCH, RICHARD;CHANG, JOSEPH