| 发明名称 |
CLASS I MHC PHOSPHOPEPTIDES FOR CANCER IMMUNOTHERAPY AND DIAGNOSIS |
| 摘要 |
<p>A set of phosphorylated peptides are presented by HLA A*0101, A*0201, A*0301, B*4402, B*2705, B*1402, and B*0702 on the surface of melanoma cells. They have the potential to (a) stimulate an immune response to the cancer, (b) to function as immunotherapeutics in adoptive T-cell therapy or as a vaccine, (c) to facilitate antibody recognition of the tumor boundaries in surgical pathology samples, and (d) act as biomarkers for early detection of the disease. Phosphorylated peptides are also presented for other cancers.</p> |
| 申请公布号 |
EP2576614(A2) |
申请公布日期 |
2013.04.10 |
| 申请号 |
EP20110787229 |
申请日期 |
2011.05.24 |
| 申请人 |
PHOSIMMUNE INC. |
发明人 |
SHABANOWITZ, JEFFREY;NORRIS, ANDREW;CUMMINGS, KARA L.;ENGELHARD, VICTOR H.;ZARLING, ANGELA;OBENG, REBECCA C.;QIAN, JIE;COBBOLD, MARK;COTTINE, JENNIFER;ENGLISH, ANN M.;HUNT, DONALD F. |
| 分类号 |
C07K14/74;A61K38/17;A61K39/395;A61P35/00;C07K7/00;C07K16/20;G01N33/68 |
主分类号 |
C07K14/74 |
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