发明名称 |
PROCESS FOR MAKING DRY AND STABLE HEMOSTATIC COMPOSITIONS |
摘要 |
Described is a process for making a dry and stable hemostatic composition, said process comprising a) providing a first component comprising a dry preparation of a coagulation inducing agent, b) providing a second component comprising a dry preparation of a biocompatible polymer suitable for use in hemostasis, c) mixing said first component and said second component under conditions effective to form a wet paste while essentially preventing degradation of the second component by said first component in a final container or transferring said wet paste into a final container, d) freezing and lyophilizing said paste in said container thereby obtaining a dry and stable hemostatic composition comprising said first and said second component in lyophilized form, and e) finishing said dry and stable hemostatic composition in said final container to a storable pharmaceutical device containing said first component and said second component in a combined form as a dry and stable hemostatic composition. |
申请公布号 |
EP2575776(A1) |
申请公布日期 |
2013.04.10 |
申请号 |
EP20110724607 |
申请日期 |
2011.06.01 |
申请人 |
BAXTER INTERNATIONAL INC;BAXTER HEALTHCARE SA |
发明人 |
GOESSL, ANDREAS;OSAWA, ATSUSHI, EDWARD;REICH, CARY, J. |
分类号 |
A61K9/16;A61K9/00;A61K9/19;A61K38/48;A61L24/10;A61P7/04 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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