PREPARATION METHOD OF PHARMACEUTIALS

摘要

A method for manufacturing an oral disintegrating preparation, comprising: (a) molding a complex aluminum substrate material with blister molding equipment, forming a plurality of depressions in said complex aluminum substrate material, wherein said complex aluminum substrate material comprises an intermediate aluminum layer, and first and second outer layers, wherein the material of the first outer layer differs from that of the second outer layer, and the flexural rigidity of the first outer layer differs from that of the second outer layer by 0-30%; (b) filling liquid pharmaceuticals into the depressions formed in step (a); (c) freezing the pharmaceuticals; (d) freeze-drying the pharmaceuticals; (e) attaching a lidding material to said package material to seal the pharmaceuticals.