| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to a method of producing N-formyl-1-amino-3,5-dimethyladamantane, an intermediate product in the overall process of producing 1-amino-3,5-dimethyladamantane hydrochloride (memantine). The disclosed method involves the following steps: (a) reacting 1,3-dimethyladamantane with an acid mixture containing concentrated sulphuric acid and concentrated nitric acid, wherein 1 to 6 volume parts of sulphuric acid (measured in ml) are used per weight part of 1,3-dimethyladamantane (measured in g); (b) reacting the solution from step (a) with an amount of formamide varying from 1 to 5 molar equivalents per mole of deprotonated 1,3-dimethyladamantane from step (a) to obtain N-formyl-1-amino-3,5-dimethyladamantane; at step (b), the molar ratio of the total amount of acid, i.e. the molar amount of sulphuric acid and the molar amount of nitric acid, taken together, to the molar amount of formamide is at least 1.5. Also disclosed is a method of producing memantine of high purity (99.7%) from 1,3-dimethyladamantane by hydrolysis of the obtained N-formyl-1-amino-3,5-dimethyladamantane.EFFECT: obtaining memantine of high purity.2 cl, 2 ex, 2 dwg |
