发明名称 |
Process for the preparation of optically active compounds using transfer hydrogenation |
摘要 |
A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drug substances. In particular, the process relates to the preparation of (S)-3-(1-Dimethylamino-ethyl)-phenol using asymmetric catalytic reduction and transfer hydrogenation, thereby providing an improved route to forming drug substances such as rivastigimine and rivastigimine hydrogen tartrate. |
申请公布号 |
US8415508(B2) |
申请公布日期 |
2013.04.09 |
申请号 |
US20090653748 |
申请日期 |
2009.12.17 |
申请人 |
MATHES CHRISTIAN;FOULKES MICHAEL;KESSELGRUBER MARTIN;NOVARTIS AG |
发明人 |
MATHES CHRISTIAN;FOULKES MICHAEL;KESSELGRUBER MARTIN |
分类号 |
C07C37/00;A61K31/095;C07C213/02;C07C269/00;C07C309/65 |
主分类号 |
C07C37/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|