发明名称 |
ANTIGEN-BINDING MOLECULE INDUCING IMMUNE RESPONSE TO TARGET ANTIGEN |
摘要 |
The inventors discovered that an immune response to an antigen was induced in a living organism having an antigen-binding molecule administered thereto, said antigen-binding molecule including an antigen-binding domain wherein the binding activity relative to the antigen changes depending on ion concentration conditions, and an FcRn-binding domain having binding activity to FcRn in pH-neutral range conditions. The inventors also discovered that, in addition to the induced immune response to the antigen, a toxic action or a growth inhibitory action on foreign organisms, cancer cells, and the like expressing the antigen to which said antigen-binding molecule binds was also found in the living organism having the antigen-binding molecule administered thereto, said antigen-binding molecule including the antigen-binding domain wherein the binding activity relative to the antigen changes depending on ion concentration conditions, and the FcRn-binding domain having binding activity to FcRn in pH-neutral range conditions. |
申请公布号 |
CA2850322(A1) |
申请公布日期 |
2013.04.04 |
申请号 |
CA20122850322 |
申请日期 |
2012.09.28 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IGAWA, TOMOYUKI;MAEDA, ATSUHIKO;HARAYA, KENTA;TACHIBANA, TATSUHIKO |
分类号 |
A61K39/395;A61P35/00;A61P43/00;C07K16/28;C07K16/46;C12N15/09 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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