The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I) or a pharmaceutically acceptable salt thereof.
申请公布号
WO2013049720(A1)
申请公布日期
2013.04.04
申请号
WO2012US58119
申请日期
2012.09.28
申请人
VERTEX PHARMACEUTICALS INCORPORATED;CHARRIER, JEAN-DAMIEN;STORCK, PIERRE-HENRI;STUDLEY, JOHN;PIERARD, FRANCOISE, YVONNE THEODORA MARIE
发明人
CHARRIER, JEAN-DAMIEN;STORCK, PIERRE-HENRI;STUDLEY, JOHN;PIERARD, FRANCOISE, YVONNE THEODORA MARIE