发明名称 |
ANTI-PCSK9 ANTIBODIES WITH pH-DEPENDENT BINDING CHARACTERISTICS |
摘要 |
The present invention provides antibodies and antigen-binding fragments thereof that specifically bind human proprotein convertase subtilisin/kexin type 9 (hPCSK9) which do not exhibit enhanced binding affinity for hPCSK9 at acidic pH relative to neutral pH. In certain embodiments, the antibodies and antigen-binding fragments of the invention bind hPCSK9 with a lower affinity at acidic pH than at neutral pH. |
申请公布号 |
US2013085266(A1) |
申请公布日期 |
2013.04.04 |
申请号 |
US201213690585 |
申请日期 |
2012.11.30 |
申请人 |
REGENERON PHARMACEUTICALS, INC.;REGENERON PHARMACEUTICALS, INC. |
发明人 |
SLEEMAN MARK W.;MARTIN JOEL H.;HUANG TAMMY T.;MACDONALD DOUGLAS |
分类号 |
C07K16/40 |
主分类号 |
C07K16/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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