Micro-electrode grid array for top and bottom recording from samples

摘要

A mixed micro-fluidic multi-electrode grid array (MEGA) device (10) suitable for holding a tissue slice (6) and for recording and/or stimulating neuron cells from said tissue slice (6), the MEGA device (10) comprising at least a top substrate in the form of a grid (4) comprising at least an electrical and/or optical multi-electrode array and a bottom substrate in the form of a stack made of a grid (1) comprising an electrical and/or optical multi-electrode array and a backbone (2) underneath said grid (1) comprising a micro-fluidic perfusion system. Furthermore said MEGA device (10) comprises means (5) for pressing and positioning said first and second substrate together and adhering a tissue slice in between said two substrates.