| 摘要 |
The present invention relates to compounds of general formula (I) with activity against mycobacteria as potential new tuberculosis drugs to overcome problems concerning resistance and drug intolerancewherein Rand Rare, independently of each other, NOor trifluoromethyl; Rand Rare H; Ris H, a saturated linear aliphatic radical having 1-3 chain members; Ris a radicalwherein X is saturated linear aliphatic radical having 1-2 chain members; or Rand Rtogether represent bivalent radicals wherein n is 1-4:where Rand Rare, independently of each other, H, linear or branched aliphatic radical having 1-5 chain members, F, Cl, CFor salts thereof. The invention also relates to a pharmaceutical composition comprising compounds of formula (I) and to the use of said compound for preparing a medicament for therapeutic or prevention treatment of microbal infection in mammals and to a method for therapeutic or prevention treatment of microbal infection or tuberculosis infection or leprosy infection in mammals. The invention also relates to a method of the preparation of 2-NRR-4H-1,3-benzothiazin-4- ones of formula (I). |
