Dual targeting of miR-208a or miR-208b and miR-499 in the treatment of cardiac disorders or musculoskeletal disorders

摘要

594365 Provided is the use of an inhibitor of miR-208a or miR-208b and an inhibitor of miR-499 in the manufacture of a medicament for reducing a cardiac stress response in a subject in need thereof, wherein said medicament is formulated for administration to said subject and wherein the cardiac stress response is reduced in the subject within two weeks of administration of the inhibitors.