FLUORINATED AMINOTRIAZOLE DERIVATIVES AS ALXR AGONISTS

摘要

597453 The disclosure relates to fluorinated aminotriazole derivatives of formula (I), wherein A, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds. Compounds of the disclosure include: 5-Phenyl-oxazole-4-carboxylic acid { 2-[4-(1,1-difluoro-ethyl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl} -amide; 2-Methyl-5-m-tolyl-oxazole-4-carboxylic acid { 2-[4-(1,1-difluoro-ethyl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl} -amide; 5-(3,5-Difluoro-phenyl)-2-methyl-oxazole-4-carboxylic acid { 2-[5-(1,1-difluoro-ethyl)-furan-2-ylmethyl]-2H-[1,2,3]triazol-4-yl} -amide; 5-(3-Dimethylamino-phenyl)-oxazole-4-carboxylic acid { 2-[4-(1,1-difluoro-ethyl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl} -amide; 5-(4-Fluoro-phenyl)-oxazole-4-carboxylic acid { 2-[4-(1,1-difluoro-ethyl)-thiazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl} -amide and 5-(3-Dimethylamino-4-fluoro-phenyl)-2-methyl-oxazole-4-carboxylic acid { 2-[4-(1,1-difluoro-ethyl)-oxazol-2-ylmethyl]-2H-[1,2,3]triazol-4-yl} -amide. Also disclosed is the use of such compounds for the treatment of inflammatory diseases, obstructive airway diseases, allergic conditions, HIV-mediated retroviral infections, cardiovascular disorders, neuroinflammation, neurological disorders, pain, prion-mediated diseases and amyloid-mediated disorders; and for the modulation of immune responses.