USE OF DR6 AND P75 ANTAGONISTS TO PROMOTE SURVIVAL OF CELLS OF THE NERVOUS SYSTEM

摘要

593643 Disclosed is an isolated antibody or antigen-binding fragment thereof that can specifically bind to a DR6 polypeptide, wherein the antibody or fragment thereof can inhibit binding of DR6 to p75. Further disclosed is an in vitro method of promoting survival of a cell of the nervous system comprising contacting in vitro said cell with the antibody or antigen-binding fragment thereof.