发明名称 |
Compositions and methods for the delivery of nitric oxide |
摘要 |
H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas NO delivery. The engineered H-NOX proteins comprise mutations that impart altered NO or O2 ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood NO gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of NO is beneficial.
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申请公布号 |
US8404632(B2) |
申请公布日期 |
2013.03.26 |
申请号 |
US20070302004 |
申请日期 |
2007.05.21 |
申请人 |
CARY STEPHEN P. L.;BOON ELIZABETH M.;WINGER JONATHAN A.;MARLETTA MICHAEL A.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
CARY STEPHEN P. L.;BOON ELIZABETH M.;WINGER JONATHAN A.;MARLETTA MICHAEL A. |
分类号 |
C07K14/00 |
主分类号 |
C07K14/00 |
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