发明名称 2-substituted-1α,25-dihydroxy-19,26,27-trinor vitamin D analogs and uses thereof
摘要 Compounds of formula I, II or III are provided where X1, X2 and X3 are independently selected from H and hydroxy protecting groups and R1 and R2 are independently selected from H or straight or branched chain alkyl groups having from 1 to 8 carbon atoms, straight or branched chain alkenyl groups having from 2 to 8 carbon atoms, straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms, or straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms; and R3 is independently selected from straight or branched chain alkyl groups having from 1 to 8 carbon atoms, straight or branched chain alkenyl groups having from 2 to 8 carbon atoms, straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms, or straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
申请公布号 US8404666(B2) 申请公布日期 2013.03.26
申请号 US20070697434 申请日期 2007.04.06
申请人 DELUCA HECTOR F.;PLUM LORI A.;CLAGETT-DAME MARGARET;GRZYWACZ PAWEL;WISCONSIN ALUMNI RESEARCH FOUNDATION 发明人 DELUCA HECTOR F.;PLUM LORI A.;CLAGETT-DAME MARGARET;GRZYWACZ PAWEL
分类号 A61K31/59;C07C401/00 主分类号 A61K31/59
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