SYNTHESIS OF 10-alpha/beta-D-ARABINOFURANOSYL-UNDECENES AS POTENTIAL ANTI-MYCOBACTERIAL AGENTS
摘要
Disclosed herein is 10-alpha/beta-D-Arabinofuranosylundecenes of general Formula (II) or pharmaceutically acceptable salts thereof as anti-mycobacterial agents in vitro; (II) wherein R, R1 and R" are as defined herein in the specification. The present invention also discloses a simple stereoselective synthesis 10-alpha/beta-D-Arabinofuranosylundecenes of Formula (II) to target enzymes involved in the biosynthesis of cell wall of Mycobacterium and thus useful as inhibitors in the Mycobacterium tuberculosis drug development.
申请公布号
WO2013038430(A1)
申请公布日期
2013.03.21
申请号
WO2012IN00617
申请日期
2012.09.14
申请人
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH;CHEPURI, RAMANA VENKATA;SARKAR, DHIMAN;PATIL, RAHUL SHIVAJI;SARKAR, SAMPA