NOVEL ALPHA 1-ANTITRYPSIN VARIANT, PREPARATION METHOD THEREOF AND USE THEREOF

摘要

The present invention relates to a novel alpha 1-antitrypsin variant, a preparation method thereof, and a use thereof. According to the present invention, the blood half-life (t1/2) and the area under the curve (AUC) of the drug concentration vs time curve are remarkably increased by adding an N-glycosylation site in animal cells through the mutation of N-terminal 1-25 amino acids, and thus the alpha 1-antitrypsin variant has excellent stability in the body and can maintain the effect of elastase activity inhibition. Therefore, the alpha 1-antitrypsin variant of the present invention can be useful for the prevention or treatment of alpha 1-antitrypsin deficiency.