发明名称 |
METHOD OF REDUCING INTRAOCULAR PRESSURE IN HUMANS USING N6 - CYCLOPENTYLADENOSINE (CPA), CPA DERIVATIVES OR PRODRUGS THEREOF |
摘要 |
Provided herein is a method of reducing intraocular pressure (IOP) in humans using N6-cyclopentyladenosine (CPA), CPA derivatives or prodrugs or enhanced cornea permeability formulations of CPA. In one embodiment, the invention is directed to CPA derivatives or prodrugs that are permeable to the cornea. In another embodiment, the invention is directed to uses of certain compounds in human subjects for reducing and/or controlling elevated or abnormally fluctuating IOPs in the treatment of glaucoma or ocular hypertension (OHT). |
申请公布号 |
EP2569325(A1) |
申请公布日期 |
2013.03.20 |
申请号 |
EP20110760319 |
申请日期 |
2011.03.25 |
申请人 |
INOTEK PHARMACEUTICALS CORPORATION |
发明人 |
KIM, NORMAN, N.;MCVICAR, WILLIAM, K.;MCCAULEY, THOMAS, G.;JAGTAP, PRAKASH |
分类号 |
C07H19/167;A61K31/495;A61K31/7076;A61P27/02 |
主分类号 |
C07H19/167 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|