发明名称 |
PALLADIUM CATALYZED INDOLIZATION OF 2-BROMO OR CHLOROANILINES |
摘要 |
The present invention provides a method for making substituted indole compounds of general formula III comprising the step of: (a) reacting a 2-bromoaniline or 2-chloroaniline of general formula (I); wherein: X, R and R1 are defined herein with a substituted acetylene of formula (II); wherein R2 and R3 in the presence of a palladium catalyst, a ligand, and a base in a solvent at a suitable temperature to give a compound of formula (III)
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申请公布号 |
CA2558051(C) |
申请公布日期 |
2013.03.12 |
申请号 |
CA20052558051 |
申请日期 |
2005.03.14 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
LI, GUISHENG;LIU, JIANXIU;LU, ZHI-HUI;ROSCHANGAR, FRANK;SENANAYAKE, CHRIS HUGH;SHEN, MING |
分类号 |
C07D209/04;C07C237/38;C07D209/00;C07D209/12;C07D263/52;C07D401/04 |
主分类号 |
C07D209/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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