BENZODIAZEPINE DERIVATIVES TOSYLATE SALTS, THEIR POLYMORPHIC FORMS, PREPARATION METHODS AND USES THEREOF

摘要

Disclosed are tosylate salts of benzodiazepine derivatives, their polymorphic forms, preparation methods and uses thereof, in particular to a tosylate salt of 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]propionic acid methyl ester of formula (I), which is a crystalline polymorph, its preparation method and use. The crystalline polymorph of tosylate salt of the compound of formula (I) has a low solvent residue and good stability, and can be used for the clinical treatment.