METHOD FOR PRODUCING GLUCURONIC ACID CONJUGATE USING SACCHAROMYCES CEREVISIAE

摘要

Provided is a new method for producing a glucuronide, having excellent productivity and being replaceable with a method using Saccharomyces pombe, and to provide a new means used in this production method. Disclosed are: a transformed Saccharomyces cerevisiae wherein a gene coding for a UDP-glucose dehydrogenase and a gene coding for a UDP-glucose transferase are inserted in a manner such that said genes can be expressed; a transformed Saccharomyces cerevisiae wherein a gene coding for a cytochrome P450 gene is further inserted in a manner such that said gene can be expressed; and a method for producing a glucaronide that includes culturing transformed Saccharomyces cerevisiae in the presence of glucose and a substance to be conjugated, generating the glucuronide of the aforementioned substance to be conjugated.