GENOME EDITING OF A ROSA LOCUS USING ZINC-FINGER NUCLEASES
摘要
Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a DNA binding domain and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.
申请公布号
EP2563918(A1)
申请公布日期
2013.03.06
申请号
EP20110777679
申请日期
2011.04.25
申请人
SANGAMO BIOSCIENCES, INC.;SIGMA ALDRICH CO. LLC
发明人
CUI, XIAOXIA;DAVIS, GREGORY;GREGORY, PHILIP, D.;HOLMES, MICHAEL, C.;WEINSTEIN, EDWARD, J.