发明名称 |
GENE DELIVERY OF OCT4 AND SIRT1 AND PHARMACEUTICAL COMPOSITIONS THEREOF |
摘要 |
The present invention provides a method for decreasing the level of methylation of Oct4 promoter in a target cell, comprising transfecting the target cell with the combination of Oct4 cDNA and SirT1 cDNA. The invention also provides a method for inducing cytoprotective responses of a target cell, comprising transfecting the target cell with the combination of Oct4 cDNA and SirT1 cDNA. The invention further provides a pharmaceutical composition comprising Oct4 cDNA and SirT1 cDNA, or a polynucleotide comprising Oct4 cDNA and SirT1 cDNA.
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申请公布号 |
US2013052238(A1) |
申请公布日期 |
2013.02.28 |
申请号 |
US201213600842 |
申请日期 |
2012.08.31 |
申请人 |
CHIOU SHIH-HWA;CHERNG JONG-YUH;TAIPEI VETERANS GENERAL HOSPITAL |
发明人 |
CHIOU SHIH-HWA;CHERNG JONG-YUH |
分类号 |
C12N15/85;A61K9/00;A61K31/711;C12N15/54;C12N15/63 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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