发明名称 |
POLYPEPTIDES AND VECTORS FOR TARGETING HER2/NEU EXPRESSING CELLS AND USES THEREOF |
摘要 |
Various aspects of the invention provide for capsids, parvovirus capsids, hybrid parvovirus capsids, parvovirus vectors, hybrid parvovirus vectors, hybrid parvovirus particles and parvovirus particles containing polypeptides in which the sequence YCDGFYACYMDV (SEQ ID NO: 3) has been substituted into the VP2 loop of the B 19 capsid protein. Polypeptides in which the sequence YCDGFYACYMDV (SEQ ID NO: 3) has been substituted into the VP2 loop of the B 19 capsid protein are also provided (e.g., SEQ ID NO:2). Other aspects of the invention provides capsids. parvovirus capsids, hybrid parvovirus capsids, parvovirus vectors, hybrid parvovirus vectors, hybrid parvovirus particles and parvovirus particles containing a polypeptide comprising SEQ I D NO: 2. Also provided in various aspects of the invention a pharmaceutical compositions and methods of delivering therapeutic agents and/or reporter peptides/proteins to target cells. Finally, methods of treating diseases characterized by cells expression HER2/neu receptors are also provided. |
申请公布号 |
WO2012159006(A3) |
申请公布日期 |
2013.02.28 |
申请号 |
WO2012US38522 |
申请日期 |
2012.05.18 |
申请人 |
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.;WEIGEL-VAN AKEN, KIRSTEN, ARIANE KELLEY;AGBANDJE-MCKENNA, MAVIS |
发明人 |
WEIGEL-VAN AKEN, KIRSTEN, ARIANE KELLEY;AGBANDJE-MCKENNA, MAVIS |
分类号 |
C07K7/08;A61K48/00;A61P35/00;C07K19/00;C12N15/62;C12N15/864 |
主分类号 |
C07K7/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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