| 摘要 |
This invention relates to water-free, semi-solid pharmaceutical products which comprise an active ingredient selected from a 5-ALA ester and pharmaceutically acceptable salts thereof; one or more triglycerides; and optionally one or more viscosity enhancers; wherein the concentration of the active ingredient is 0.5 to 30% by weight of the total weight of the product, and the concentration of the one or more triglycerides is in the range of 60 to 96% by weight of the total weight of the product if the one or more viscosity enhancers are present, or in the range of 70 to 99.5% by weight of the total weight of the product if the one or more viscosity enhancers are not present. The invention further relates to the use of such products in the photodynamic treatment (PDT) of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, preferably in PDT of endometrial, cervical, vulvar, vaginal, anal and penile dysplasia and HPV infections of the uterus, cervix, the vulva, the vagina, the anus and the penis. |
