发明名称 Heteroaryl derivatives as DGAT1 inhibitors
摘要 <p>The invention relates to compounds of formula (I): &lt;Chemistry id="chema01" num="0001"&gt;&lt;Image id="ia01" he="46" wi="111" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /&gt;&lt;/Chemistry&gt; where A is selected from: &lt;Chemistry id="chema02" num="0002"&gt;&lt;Image id="ia02" he="37" wi="125" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" /&gt;&lt;/Chemistry&gt; and R&lt;Sup&gt;1&lt;/Sup&gt;, R&lt;Sup&gt;2&lt;/Sup&gt;, R&lt;Sup&gt;3&lt;/Sup&gt;, R&lt;Sup&gt;4&lt;/Sup&gt;, R&lt;Sup&gt;5&lt;/Sup&gt;, R&lt;Sup&gt;10a&lt;/Sup&gt;, R&lt;Sup&gt;10b&lt;/Sup&gt;, M, Z, r and s are as defined in the description, useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), for example glucose tolerance, Type II diabetes or obesity. The invention also provides pharmaceutical compositions comprising such compounds.</p>
申请公布号 EP2548618(A3) 申请公布日期 2013.02.27
申请号 EP20120180191 申请日期 2009.07.14
申请人 NOVARTIS AG 发明人 FORSTER, CORNELIA JUTTA;KWAK, YOUNG-SHIN;NAKAJIMA, KATSUMASA;WANG, BING
分类号 A61P3/10;A61K31/426;A61K31/427;A61K31/454;A61K31/4545;A61K31/506;A61P3/04;C07D213/75;C07D217/22;C07D231/40;C07D249/14;C07D277/46;C07D401/12;C07D403/12;C07D413/12;C07D417/04;C07D417/06;C07D417/12;C07D417/14;C07D471/10 主分类号 A61P3/10
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