发明名称 |
CD47 related compositions and methods for treating immunological diseases and disorders |
摘要 |
Provide herein are fusion polypeptides that comprise a CD47 extracellular domain or a variant thereof that is fused to a Fc polypeptide. The fusion polypeptides are useful for treating an immunological disease or disorder in a subject according to the methods described herein. The fusion polypeptides are capable of suppressing immunoresponsiveness of an immune cell, inhibiting production of proinflammatory cytokines, including inhibiting immune complex-induced production of cytokines.
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申请公布号 |
US8377448(B2) |
申请公布日期 |
2013.02.19 |
申请号 |
US20100687334 |
申请日期 |
2010.01.14 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANDFORD JUNIOR UNIVERSITY;SMITH CRAIG A.;WILEY STEVEN;KAYKAS AJAMETE;PROBST PETER |
发明人 |
SMITH CRAIG A.;WILEY STEVEN;KAYKAS AJAMETE;PROBST PETER |
分类号 |
A61K39/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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