发明名称 |
MARKERS FOR CANCER PROGNOSIS AND THERAPY AND METHODS OF USE |
摘要 |
The invention relates generally to the field of cancer prognosis and treatment. More particularly, the present invention relates to methods and compositions that utilize a particular panel of gene products (biomarkers) and their differential expression patterns (expression signatures), wherein the expression patterns correlate with responsiveness, or lack thereof, to chemotherapy treatment. The invention is based on the identification of a specific set of biomarkers that are differentially expressed in chemotherapy-treated tumors and which are useful in predicting the likelihood of a therapeutic response, including residual disease persistence and subsequent tumor recurrence in cancer patients receiving chemotherapy. The gene panel is also useful in designing specific adjuvant modalities with improved therapeutic efficiency. Also disclosed are methods for characterizing tumors according to expression of the biomarkers described herein.
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申请公布号 |
US2013042333(A1) |
申请公布日期 |
2013.02.14 |
申请号 |
US201213463129 |
申请日期 |
2012.05.03 |
申请人 |
JUDDE JEAN-GABRIEL;CAIRO STEFANO;LEGRIER MARIE-EMMANUELLE |
发明人 |
JUDDE JEAN-GABRIEL;CAIRO STEFANO;LEGRIER MARIE-EMMANUELLE |
分类号 |
C12Q1/68;A01K67/00;A61K31/7072;A61P35/00;C40B30/04;G01N33/574 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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