发明名称 |
CARRIER-LINKED CARBAMATE PRODRUG LINKERS |
摘要 |
The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aromatic hydroxyl group is conjugated to one or more polymeric carriers via secondary carbamate-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments.
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申请公布号 |
US2013035635(A1) |
申请公布日期 |
2013.02.07 |
申请号 |
US201113574120 |
申请日期 |
2011.01.21 |
申请人 |
ASCENDIS PHARMA A/S;RAU HARALD;LESSMANN TORBEN |
发明人 |
RAU HARALD;LESSMANN TORBEN |
分类号 |
A61K31/27;A61K31/4015;A61M5/31;A61P29/00;C07C271/52;C07D207/416 |
主分类号 |
A61K31/27 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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