发明名称 |
OLIGOSACCHARIDES AND OLIGOSACCHARIDE-PROTEIN CONJUGATES DERIVED FROM CLOSTRIDIUM DIFFICILE POLYSACCARIDE PS-I, METHODS OF SYNTHESIS AND USES THEREOF, IN PARTICULAR AS VACCINES ANDDIAGNOSTIC TOOLS |
摘要 |
The invention relates to a synthetic oligosaccharide representing part of the repeating unit of the Clostridium difficile glycopolymer PS-I and having the sequence of the pentasaccharide a-L-Rhap- ( 1?3 ) -ß-D-Glcp- ( 1?4 ) - [a-L-Rhap- ( 1?3 ] -a-D-Glcp- ( 1?2 ) -a-D-Glcp or a synthetic fragment or derivative thereof. Preferably, the claimed synthetic oligosaccharide bears at least one linker L for conjugation to a carrier protein or for immobilization on a surface. Further aspects of the invention relate to advantageous methods for synthesizing said synthetic oligosaccharide and oligosaccharide-protein conjugate as well as to uses thereof, in particular as vaccines and diagnostic tools. |
申请公布号 |
CA2843908(A1) |
申请公布日期 |
2013.02.07 |
申请号 |
CA20122843908 |
申请日期 |
2012.07.30 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. |
发明人 |
SEEBERGER, PETER H.;MARTIN, CHRISTOPHER E.;BROECKER, FELIX;ANISH, CHAKKUMKAL |
分类号 |
C07H3/06;A61K31/7032;A61P1/12;A61P31/04;C07H3/08;C07H13/08;C07H15/04;C07H15/20 |
主分类号 |
C07H3/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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