| 摘要 |
Cardiovascular activity is exhibited by compounds having the formula <IMAGE> and pharmaceutically acceptable salts thereof, wherein R1 is alkyl, cycloalkyl, aryl, heterocyclo, -(CH2)n-Y2, -(CH2)p-Y3 or halo substituted alkyl; R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, -(CH2)n-Y1, or halo substituted alkyl; R3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, -(CH2)n-Y2, -(CH2)p-Y3, or halo substituted alkyl; R4 is aryl or heterocyclo; R5 is hydrogen, alkyl, aryl, arylalkyl, cyano, nitro, <IMAGE> +TR <IMAGE> Y1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl-(CH2)m-O-, mercapto, alkylthio, aryl-(CH2)m-S-, amino, substituted amino, carbamoyl, <IMAGE> <IMAGE> +TR <IMAGE> Y2 is cycloalkyl, aryl, heterocyclo, carbamoyl, <IMAGE> +TR <IMAGE> Y3 is hydroxyl, alkoxy, aryl-(CH2)mO, mercapto, alkylthio, +TR <IMAGE> amino, or substituted amino; m is 0 or an integer of 1 to 6; n is an integer of 1 to 6; and p is an integer of 2 to 6.
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